Repeated noise stress alters metabotropic glutamate receptor binding in rat brain
نویسندگان
چکیده
منابع مشابه
A single social stress-experience alters glutamate receptor-binding in rat hippocampal CA3 area.
The distribution of glutamate receptors in the rat hippocampus was investigated 24 h after the social stress of confrontation with a dominant opponent. AMPA-type glutamate receptors were labeled with the antagonist [3H]CNQX, and NMDA-type receptors were labeled with the competitive antagonist [3H]CGP39653. Increased [3H]CGP39653 labeling was exclusively found in the CA3 stratum radiatum and a d...
متن کاملModulation of Glutamate Transport and Receptor Binding by Glutamate Receptor Antagonists in EAE Rat Brain
The etiology of multiple sclerosis (MS) is currently unknown. However, one potential mechanism involved in the disease may be excitotoxicity. The elevation of glutamate in cerebrospinal fluid, as well as changes in the expression of glutamate receptors (iGluRs and mGluRs) and excitatory amino acid transporters (EAATs), have been observed in the brains of MS patients and animals subjected to exp...
متن کاملIn vitro binding characteristics of a new selective group II metabotropic glutamate receptor radioligand, [3H]LY354740, in rat brain.
The in vitro binding of [3H]LY354740, the first high affinity group II-selective metabotropic glutamate (mGlu) receptor radioligand, was characterized in rat cortical, hippocampal, and thalamic membranes as well as in rat brain sections. [3H]LY354740 binding was saturable in all regions investigated. Nonspecific binding (in the presence of 10 microM DCG-IV) was approximately 8% of the total. Io...
متن کاملIn Vitro Binding Characteristics of a New Selective Group II Metabotropic Glutamate Receptor Radioligand, [H]LY354740, in Rat Brain
The in vitro binding of [H]LY354740, the first high affinity group II-selective metabotropic glutamate (mGlu) receptor radioligand, was characterized in rat cortical, hippocampal, and thalamic membranes as well as in rat brain sections. [H]LY354740 binding was saturable in all regions investigated. Nonspecific binding (in the presence of 10 mM DCG-IV) was '8% of the total. Ionotropic glutamate ...
متن کامل[3H]LY341495 binding to group II metabotropic glutamate receptors in rat brain.
[3H]LY341495 is a highly potent and selective antagonist for group II metabotropic glutamate (mGlu) receptors (mGlu2 and mGlu3), which has been used to label these receptors in cells expressing recombinant receptor subtypes. In this study, we characterized the kinetics, pharmacology, and distribution of [3H]LY341495 binding to mGlu receptors in rat brain tissue. Equilibrium experiments in the r...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1997
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)45616-3